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Information, effects, deficiency, dosage, side effects
Ribose, also called D-ribose, is a simple monosaccharide with 5 carbons, also called pentose. It is used by all cells of the body and is an important part of the energy metabolism. Ribose also provides the structural backbone of our genetic material, DNA and RNA, certain vitamins and other important cell connections.
Ribose can improve the quality of life by increasing the energy of the body's cells. Regardless of whether you are a triathlete or a retiree, the effects of a lack of energy are real and can seriously affect your health and vitality.
Ribose is a vital substance that energizes the body on a basic level. It is the vital structural backbone of important cell connections called purines and pyrimidines. No other compound can replace ribose in the important task of regulating the metabolic processes involved in the synthesis of purines and pyrimidines.
Our body must have an adequate supply of purines and pyrimidines to produce important cellular components such as our genetic material (DNA and RNA), numerous co-factors, certain vitamins and, most importantly, adenosine triphosphate (ATP), the 'energy currency' of the cells.
Without these vital structural components, our body would quickly run out of energy, it would not be able to produce proteins and our cells would lose the ability to split into parts.
Ribose or D-ribose is a simple sugar that forms the carbohydrate portion of the DNA and RNA. It is at the beginning of the metabolic process that leads to the formation of adenosine triphosphate (ATP). ATP is the universal source of energy for all living cells.
Ribose is produced in the body by various metabolic processes, which begin with the breakdown of glucose with the help of oxygen. Without ribose, the build-up of ATP storage in the cells would be impossible.In the event of an insufficient supply of oxygen to the body from the blood, ATP production may no longer function properly, with the result that the universal energy storage is emptied and the body has to find other, less effective forms of energy production.
In the event of an insufficient supply of oxygen to the body from the blood, ATP production may no longer function properly, with the result that the universal energy storage is emptied and the body has to find other, less effective forms of energy production.
The splitting of ATP over ADP, AMP and the individual components of adenine, hypoxanthine and inosine produces an ever smaller amount of energy from stage to stage.
In order to rebuild the cellular energy storage, a so-called re-synthesis must take place; AMP is restructured into ATP using the intermediate step ADP.
If physical stress or a lack of oxygen supply persists, the synthesis will start late, namely after the breakdown of AMP into its individual components. This re-synthesis, also called de novo, can take a few days under special conditions.
A sufficient presence of ribose is in any case necessary for the reconstruction and refilling of the energy storage. Studies have shown that the recovery phase was significantly shortened when ribose was administered to ischemia patients.
All vital connections are made in the body through a series of complicated, biochemical, metabolic pathways. Ribose is no exception.
In the body, ribose is made from glucose (a simple 6-carbon sugar) via the metabolic pathway, which is called the pentose phosphate pathway (PPP) or the hexose monophosphate cycle (HMS).
The formation of ribose in the heart and muscle cells is a slow process. Unfortunately, important enzymes that regulate the activity of this path are missing in the heart and muscle cells.
This delay in ribose synthesis in the heart and muscle tissue also delays the restoration of energy when energy stores are depleted due to illness or exercise.
The physiologically functional form of ribose called 5-phosphoribosyl-1-pyrophosphate (PRPP) regulates the metabolic pathway that synthesizes the energy compounds in all living tissues.
This path is called the purine nucleoside path (PNP). If PRPP is not available in sufficient quantities, energy synthesis slows down and tissue recovery is delayed.
If the cellular energy storage is used up due to an illness, exhaustion or training, it must be refilled. PRPP is necessary to stimulate the metabolic pathway used by the body to replenish these energy storages.
Ribose bypasses the slow and restrictive pentose phosphate pathways, forms PRPP very quickly and speeds up the process of energy synthesis.
Ribose is the most important source of energy for our body. If our heart is not adequately supplied with ribose, it can't meet their high energy demand.
The heart's ability to maintain energy is limited by one factor: the availability of RIBOSE.
Our bodies naturally produce ribose, but in times of stress, the need to compensate for the loss of energy through the cells is greater than what we offer. That is why taking ribose as a dietary supplement is so important.
Numerous medical studies conducted in the United States and Europe have shown that heart energy levels can be drastically reduced through training or changes in the normal cellular energy metabolism.
Depleted cardiac energy storages are associated with increased cardiac stress, reduced blood flow to the periphery of the body, exhaustion and less exercise. Ribose is the main nutrient for restoring cardiac energy.
To maximize athletic performance or to keep energy storages full during strenuous activities, slightly higher doses may be necessary.
Ribose should be taken just before or immediately after training or physical activity. For longer training sessions, an additional 1 - 2 grams per training hour could be helpful.
There are two known side effects of ribose when doses of 10 grams or more are taken on an empty stomach. The first is transient hypoglycemia (low blood sugar levels), which can be prevented if higher doses of ribose are combined with other carbohydrates (such as juice).
The second side effect that some people experience is loose stool. This side effect was only reported when very high doses (over 10 grams) were taken. The total daily intake of ribose should be limited to 20 grams or around 4 heaped teaspoons.
Ribose should be taken in single doses of up to 5 grams (around 1 heaped teaspoon). Multiple doses of 5 grams taken 30 - 45 minutes apart can be taken without side effects.
For some people, high intensity training means daily training for a marathon, 10 km run or a triathlon. For others, it means going to the mailbox, climbing stairs or spending a day at the mall. However, for most of us it simply means stressing our muscles beyond normal levels.
Regardless of how you define high intensity, the effect on our body is the same. Intensive exertion strains our muscles and makes it difficult for them to remain energized.
The resulting imbalance between the supply of energy and the demand for energy leads to a decrease in energy, which leads to the depletion of cellular energy reserves.
This loss of cellular energy is a catastrophe, because this energy can only be recharged slowly and at a metabolically expensive cost.
Ribose increases the natural process of energy synthesis in the body. It helps reduce energy loss during stress and accelerated energy and tissue recovery.
Ribose helps the muscles regenerate lost energy and potentially minimize the physiological consequences of this low-energy situation.
Whether you are running a marathon in under three hours or do a daily workout that keeps your heart and muscles healthy, Ribose can help you keep your muscles energetic and strong.
Everyone needs ribose. It is an essential ingredient for stimulating the natural energy production. Research has shown that ribose reduces stress associated with strenuous activity and helps athletes achieve new top performances.
Ribose helps the heart and muscles maintain healthy energy levels and accelerates energy recovery when the tissue is stressed by strenuous exercise or overuse.
Regardless of whether you are a trained athlete, a weekend athlete or someone who is concerned about their cardiovascular health, ribose can give you the energy that your body needs.
Scientific research shows that three to four training sessions per week does not mean enough rest periods between the units, which means that the energy storages of the heart and muscles can't reach their normal levels.
Taking ribose shortens the time it takes for the heart and muscle tissue to replace the energy lost through intense exercise.
Keeping the energy storages full ensures that the heart and muscles are in a good physical condition, increases strength and endurance and reduces fatigue.
Current research has shown that taking a ribose supplement during exercise reduces free radical formation.
Ribose can increase the effects of creatine and other energy supplements because the energy storage is kept at full capacity. Creatine works by recycling energy that is already in the tissues.
Another dietary supplement, carnitine, helps metabolize fatty acids. Others, such as pyruvate and coenzyme Q10, also help recycle energy.
None of these other nutritional supplements actually help produce the energy components that the cell needs to maintain a healthy energy storage. Only ribose has this important metabolic function.
Remember: Ribose helps the body produce energy, while other supplements can help the body use energy more efficiently.
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